20h • General discussion
Stack for mitochondria
- Epithalon targets telomerase activation and melatonin restoration — a speculative longevity approach with a single-lab evidence base.
- SS-31 (Elamipretide) targets cardiolipin stabilization in the mitochondrial inner membrane — an FDA-approved therapy (Barth syndrome, September 2025) with Phase 2/3 clinical trial data.
- These are complementary mechanisms: one addresses chromosomal aging (telomeres), the other addresses cellular energy aging (mitochondria).
- SS-31 has substantially stronger independent evidence; Epithalon has intriguing mechanistic theory but requires caution around evidence quality.
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Stack for mitochondria
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