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10 contributions to BIOHACKING | TONY HUGE
Telmisartan on Cycle: The Blood Pressure Drug Worth Understanding Properly
Someone asked in Discussion whether telmisartan should be a staple on TRT and blast, and whether you become dependent on it. Good question, and the answer is more interesting than "it lowers blood pressure." Up front: telmisartan is a prescription drug. Everything below includes dosages, including my own, because pretending dose information does not exist does not protect anyone. It just means people get the number from a forum without the warnings attached. The warnings are the part most sources skip, so read to the end. WHY BLOOD PRESSURE IS THE THING TO WATCH The HAARLEM study followed men through real anabolic steroid cycles with echocardiography before, at the end, and a year later. During the cycle, systolic blood pressure rose about 6 mmHg and diastolic about 5 mmHg. Left ventricular mass rose roughly 28 grams, and the increase tracked with dose. Ejection fraction dropped about 5 percent. The good news is that most of it reversed after the cycle. The bad news is that reversal was observed in men who came off. If you blast and cruise for years, you are holding the system in the stressed state and never running the recovery arm of that experiment. So blood pressure is not a side issue on cycle. It is the main cardiovascular lever, and unlike a lot of what gets discussed here, it is cheap to measure and treatable with drugs that have decades of outcome data. THIS IS LAW 1, GOVERNORS VS ACCELERATORS Every system has accelerators and governors. The accelerator is obvious: androgens, growth factors, training, food. The governor is what limits how long you can keep your foot down. On cycle the governors are blood pressure, cardiac remodeling, lipids, and hematocrit. Most people spend all their attention on the accelerator and none on the governor, then wonder why the car is shaking. Managing blood pressure is not a side quest. It is what determines how many years you get to keep pushing the accelerator at all. WHAT TELMISARTAN ACTUALLY IS Telmisartan is an angiotensin receptor blocker. Angiotensin II is the signal that constricts blood vessels and drives aldosterone and sodium retention. Telmisartan blocks it at the AT1 receptor, so vessels relax and pressure drops.
0 likes • 2d
Telmisartan Never heard of it
BPC157
1 week in 500mcg per day not seeing any difference?
0 likes • 7d
And is 500mcg enough?
0 likes • 4d
@Miroslav Petrovic I’ve just upped the dose
Thinking about just getting on 100mg of TRT
Names the benefits of trt 100mg of test cipyanate I know the side effects insomnia, sleep apnea, high blood pressure, anxiety, I really need to just get on the injectables I'm just nervous about the side effects but everybody tells me you feel amazing on it I want to feel that
2 likes • 6d
Micro dose I take 14mg per day and my test results came back 721 ng/dL
0 likes • 5d
@Carlos Salinas nothing all levels are spot on, I’d probably like a little bit more if I’m honest we will see at my next check in
Best Long-Term Protocol After Coming Off TRT?
For anyone who has come off TRT, what have you found to be the best long-term protocol afterward? I’m coming off after 7 years . I understand nothing is going to fully replace TRT, so I’m not looking for the obvious “just stay on TRT” answer. I’m curious about combinations of things like HCG, enclomiphene, peptides, supplements, or anything else that people have actually used long term to get as close as reasonably possible to the benefits they had on TRT while maintaining natural testosterone production. What combination worked best for you, what doses/frequency did you use, how long have you stayed on it, and what did your labs look like compared with TRT? Also interested in libido, energy, mood, body composition, strength, and any side effects. Basically, if you were building the best sustainable post-TRT protocol possible, what would it look like?
1 like • 14d
Question I’d have is why do you want to come off
SS-31
Thinking of running an SS-31 cycle pre MOTS-C what are the recommended protocols looking on line things seem to vary quite a bit would be interesting to see what people are running
0 likes • 15d
@Ray Munoz there’s allot of evidence for high doses?
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Chris Fitzpatrick
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