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Black Box Biohacking
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66 contributions to BIOHACKING | TONY HUGE
4d •
What's actually wrecking your sleep?
Every anabolic signal you paid for gets executed while you're asleep. Growth hormone, tissue repair, recovery. Run on six broken hours and you're spending money to watch it burn. Vote on your biggest sleep problem below, then comment with what you've already tried: magnesium, ashwagandha, DSIP, ipamorelin, anything. I read these and use them to decide what to cover next. If you want a starting point, Protocol 09 (Sleep & Longevity) is in the Classroom: https://www.skool.com/biohacking-tony-huge/classroom/923d0785?md=cfe08ad2f8734801a8eab7180b4a571a
Poll
51 members have voted
4 likes • 4d
Great conversation Tony! I’ve tracked my sleep with an Oura Ring for about 10 years and my sleep hygiene is pretty dialed in. My two main issues are: 1. Waking between 3–6am and sometimes being unable to get back to sleep. 2. Nocturia, despite investigating it extensively without finding an obvious cause. I’ve started thinking about sleep less as “which sleep aid works?” and more as which biological sleep lever is actually driving the problem. At the moment I see eight main categories: 1. Histamine / wake-drive blockers — mirtazapine, diphenhydramine, low-dose doxepin. Mirtazapine worked exceptionally well for keeping me asleep, but the half-life was too long and I felt groggy for days. 2. Orexin antagonists — daridorexant, lemborexant, suvorexant. These seem interesting for people who fall asleep easily but wake early and suddenly feel switched on. 3. Noradrenergic / threat-arousal reducers — prazosin, clonidine, guanfacine. Relevant where awakenings involve vivid dreams, pounding heart, adrenaline or sudden alertness. 4. Melatonin / circadian agents — melatonin, ramelteon, agomelatine. Melatonin helps me fall asleep quickly, but doesn’t reliably keep me asleep. 5. GABA / inhibitory compounds — gabapentin, pregabalin, eszopiclone, zolpidem, phenibut etc. I generally respond well to GABA-related substances, so this pathway may be relevant too. 6. Neurosteroid / hormonal signalling — pregnenolone, progesterone/allopregnanolone-related pathways, testosterone/estradiol state. Hormonal state seems to have a noticeable effect on sleep and nervous-system regulation, so I think this pathway is worth considering too. 7. Peptides / circadian-regulation compounds — DSIP, Epitalon, Pinealon, Selank/Semax depending on the goal. These seem to influence sleep architecture, circadian rhythm or nervous-system regulation through somewhat different mechanisms. 8. Supplements / nutrients — magnesium, glycine, inositol, phosphatidylserine, theanine, GABA, taurine, apigenin etc. These can influence inhibitory tone, stress signaling or sleep architecture, although responses seem very individual.
0 likes • 3d
@Geoff Maxwell thanks for sharing. How’s that work out for you? What benefits have you noticed?
7d •
Thoughts on FLGR-242 for muscle building?
I’m hearing a lot of positive results on the follistatin inhibitor FLGR-242 for muscle building. Anyone heard of it or used it?
0 likes • 5d
@Trey Wilson thanks for sharing your thoughts
1 like • 5d
@Tony Huge thanks for clearing up my questions! I appreciated the invitation, message sent
5d •
Dual Orexin Receptor Antagonist (DORA)
Does anyone know a reliable source in the US for a dual orexin receptor antagonist for sleep, specifically daridorexant (Quviviq), lemborexant (Dayvigo), or suvorexant (Belsomra)? I’m particularly interested in whether any research-chemical companies sell properly dosed capsules/tablets with independent testing, rather than raw powder. Also interested in people’s experience with these for sleep maintenance / early-morning waking, especially whether they caused less next-day grogginess than antihistamine-type sleep meds? Thanks
25d •
I Think Ramelteon Is One of the Most Overlooked Sleep Molecules
Most people reach for melatonin when they are trying to fall asleep faster. But Ramelteon is interesting because it targets the same MT1 and MT2 receptors while binding much more tightly in the research I went through. And unlike GABA based sleep drugs, it is working through the brain’s natural clock pathway. That matters to me. Instead of just forcing sedation, the idea is to strengthen the signal telling your brain that it is time to sleep. The human trials are also pretty interesting. People with chronic insomnia fell asleep faster compared with placebo, and a longer study did not show rebound insomnia when they stopped using it. That does not mean it is right for everyone. There are still interactions and contraindications to pay attention to, especially with certain medications, which I cover in the video. But for something FDA approved since 2005, I am surprised more people in the biohacking space are not talking about it. Full breakdown: https://www.youtube.com/watch?v=FHEK3BbGKCw Community question: Before this video, had you ever heard of Ramelteon? And if you have tried it, how did it compare with melatonin for you?
1 like • 24d
Thanks @Tony Huge where can I buy it from?
0 likes • 24d
@Tony Huge awesome, thanks!
Aug 26 •
Share Your Transformation
We want to see your progress. If you’ve made a transformation since joining the community, share your before-and-after photos in the comments below. You can also send them to us through DM if you’d rather keep them private. Feel free to include a short description of what changed, what helped you the most, and how long you’ve been working on it. We’d love to highlight more real success stories from inside the community.
1 like • Aug 27
@Keith Griffin II Great work bro!
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@dean-arcan-9197
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Active 1d ago
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