Hello Dr., I have a question about which estrone test should be used with your E1 + E2 target of 40–100. I didn't know if the Estrone serum assay test or the LC/MC test were similar, so I just got both tests. In this case, just an example, The Estrone by LC-MS/MS was 17 pg/mL And yet, the Standard serum estrone by EIA was 81 pg/mL Given the large discrepancy between these two methods, I am not sure which one to use for the E1+E2 formula. Which estrone method did you intend for your formula: LC-MS/MS or the standard serum immunoassay? And for the estradiol I assume its LC-MS/MS? And I'm also curious to know about how these two tests can result in such different numerical amounts - if you have any insight behind that. Thank you

Hello Dr., I'd love to hear some of your thoughts the common mental health conditions such as OCD, anxiety and depressive disorders, etc. In my own experience, and from my close male friends, it seems that certain SSRI and related medications are constantly prescribed and pushed. Would you say that optimizing HRT would be far more helpful in dealing with such conditions, or cases where these conditions are more mild or psychological/mindset related. And on the topic of OCD, is that a special case where you see immunotherapy or other types of treatments more appropriate than what is common treatment? Thank you

Hello Dr., I'd like to know if you think the BPC 157 and TB500 blend can be injected sub-q around the belly for a systemic affect of repairing tendons throughout the whole body. Or, must it only be applied to the specific muscle/area where that is injured? I'm also curious to know if you have tried these, especially for tendon injuries or tears, and if you know of any bad side effects that may come with these. Alternatively, do you know of other similar compounds that do the same, or better job, at tendon repair throughout the body? In what cases would you recommend someone to take these, and what possible risks should we be on the look out for. Thank you

Hello Dr., After watching your recent videos on more thyroid related topics, I would like to know more about this. Even if we have never been told by doctors that something is wrong with our thyroid, it was my first time learning from your videos that some sort of deficiency or problem with thyroid can be concluded from simply feeling chronically tired. Would you say that similar to testosterone, thyroid hormone has become a issue in recent years compared to the many generations before? I have been categorizing my own chronic tiredness at times, especially from going outside in and social situations, as just being "introverted". I feel fine when going to the gym or exercising on the other hand. Perhaps this is something that most people have and just haven't been told about? I would love to know more about the function of the thyroid, how to self assess if its working properly, whether we need exogenous thyroid hormone based on specific feelings of exhaustion, and if there are any side effects with taking thyroid hormone (negative or positive effects as well). I'm glad that you started making more videos about this as I likely would not have learned about this topic otherwise. Thank you

Hello Dr. Ty, just a repost from before where I wanted to hear your thoughts on this topic. Mainstream advice usually describes LDL as “bad,” HDL as “good,” and saturated fat and dietary cholesterol as unhealthy. At the same time, the mainstream ApoB model argues that greater lifetime exposure to ApoB-containing particles directly causes plaque. I've also heard the warnings against red meat, eggs, and other high cholesterol foods for similar problems. Could you explain how you believe atherosclerosis actually develops? What roles do LDL-C, ApoB, HDL, small dense LDL, oxidized LDL, inflammation, insulin resistance, blood sugar, and endothelial damage each play? Is a high ApoB particle count dangerous by itself, or mainly when combined with glycation, oxidation, and metabolic dysfunction? From a practical perspective, what should people actually watch throughout their lives to prevent atherosclerosis? Which blood markers and lifestyle factors matter most, and which commonly discussed cholesterol markers are misunderstood or given too much importance? I would also like your opinion on the carnivore diet. Do you believe eating only meat and other animal foods is the optimal human diet? Are fatty meat, eggs, saturated fat, and dietary cholesterol generally healthy even when they raise LDL-C or ApoB? Some carnivore advocates argue that plants contain natural pesticides, anti-nutrients, and potentially carcinogenic defense chemicals that may gradually harm humans over many years, even if there are no obvious short-term symptoms, and that humans spent long periods of the Pleistocene eating a heavily animal-based diet and became well adapted to it, whereas agriculture greatly increased our reliance on domesticated grains and carbohydrate-heavy foods in more recent years (of human history). I also remember hearing that 4–5 grams of glucose circulates in the blood at a given time, and that the body can manufacture the glucose it needs without dietary carbohydrates. Is that being interpreted correctly? Does it mean repeated large glucose and insulin spikes from high-carbohydrate foods are harmful, or does that confuse the amount circulating at one moment with the body’s total glucose use?