I believe it was Stanley Jacob, DMSO pioneer, who used DMSO or DMSO/Water combination as the ultrasound coupling agent. He found it worked better with ultrasound. There is some research literature on this, e.g. https://pubmed.ncbi.nlm.nih.gov/19900747/ Has anybody had experience doing this? I'm especially thinking about whether repeated DMSO contact is compatible with the complete US Pro 2000 applicator. Any experience appreciated.