Perimenopausal woman here 🙋🏻‍♀️ I can give you actual firsthand experience. I also have autoimmune disease, chronic inflammation and unstable blood sugar despite not being diabetic, so my energy problems have several moving parts. For energy, the most noticeable and repeatable combination for me has been NAD+ and L-carnitine together. I had used them separately, but taking them together was when I finally noticed sustained energy and an overall GREAT feeling without feeling overstimulated or crashing later. I now use both consistently because maintaining a steadier level works much better for me than taking larger amounts only a few times a week. For mental clarity and focus, Semax has helped me. For calm, anxiety and emotional regulation, Selank has been the better fit. I use Semax and Selank together five days on and two days off because they complement each other really well for me—clearer brain without feeling wound up. I call the combination my Brain Calm. 😂 Oxytocin has also made a VERY noticeable difference in my mood, connection, affection and irritability. That one surprised me because my family noticed the difference before I fully did. When I ran out, the anger and irritability started creeping back in almost immediately. It doesn’t necessarily create energy, but being calmer and not constantly emotionally overloaded definitely leaves me with more energy for everything else. I also use glutathione for antioxidant and cellular support. I don’t “feel” it as immediate energy the way I feel NAD+ with L-carnitine, but I consider it another piece of the puzzle. Low-dose tirzepatide has helped reduce my inflammation and stabilize my blood sugar, which indirectly changed my energy and how well I function. I am not diabetic, but I have dealt with unstable blood sugar and sudden drops since I was 19. I also have MCTD and chronic inflammation, so sometimes improving “energy” is really about dealing with all the things draining it in the first place. For complete honesty, PE-22-28 was NOT a winner for me. I completed the full month, but I knew within the first week that it didn’t seem to be helping and might actually be making things worse. It made me feel emotionally flat, and that continued throughout the cycle. I finished it so I could give it a fair shot, but I did not continue it. I was also not a fan of PT-141 at all. MOTS-c was also not kind to me so I only took it three times before deciding it wasn't for me either.

@Jesse Walton You’re welcome! Mine is a pretty extensive stack right now because I’m also addressing MCTD, chronic inflammation, pain, hormone changes and non-diabetic blood-sugar instability—not only energy, clarity and mood. My current personal protocol is: NAD+: 100 mg Monday–Friday L-carnitine: 300 mg Monday–Friday Glutathione: 300 mg Monday/Wednesday/Friday Semax: 500 mcg each morning Selank: 500 mcg morning and evening Oxytocin: 200 mcg evening Tirzepatide: 3 mg weekly (considering bi weekly split to have a more steady amount with less dumps because it helps with inflammation and pain and near shot day my pain starts increasing) KPV: currently 450 mcg daily BPC-157: 500 mcg morning and evening Kisspeptin: 200 mcg Monday/Wednesday/Friday I generally use Semax and Selank five days on/two days off. Kisspeptin is four weeks on/three weeks off, glutathione eight weeks on/four weeks off, and NAD+ and oxytocin 12 weeks on/four weeks off. My most repeatable energy response comes from taking NAD+ with L-carnitine, but some people respond to NAD+ with glutathione the way I respond to NAD+ with L-carnitine. For me, glutathione is helpful support, while NAD+ and L-carnitine together create the noticeable sustained energy and overall GREAT feeling. I added everything separately and worked up to these amounts based on my own response. I definitely would not have your wife begin an entire stack at once because then you won’t know what is helping, doing nothing or making her feel worse. This is just what currently works for me. It took some trial, error research and time to fine-tune this to where I feel good consistently with more good days than bad.