The scale tells you how much weight you lost. It doesn't tell you what you lost, and on GLP-1 drugs a real chunk of it isn't fat. THE SCIENCE Semaglutide (STEP 1, human RCT, DXA substudy of 140 people, 2.4 mg weekly as the dose studied, 68 weeks): total fat mass fell 19.3% and lean body mass fell 9.7% from baseline. Fat went down about twice as fast as lean, which is good news, but lean tissue still dropped meaningfully. Semaglutide 2.4 mg is FDA-approved for chronic weight management (Wegovy). Tirzepatide (SURMOUNT-1, human RCT, DXA substudy of 160 people, pooled 5/10/15 mg doses studied, 72 weeks): body weight fell 21.3% vs 5.3% on placebo. Fat mass fell 33.9% and lean mass fell 10.9%. Roughly 75% of the weight lost was fat and 25% was lean mass, and that split held across sex and age subgroups. Tirzepatide is FDA-approved for chronic weight management (Zepbound). Retatrutide (GLP-1/GIP/glucagon) is still investigational and not FDA-approved, so detailed body-composition data are still coming. Two honest caveats: DXA "lean mass" includes water and organs, not just skeletal muscle, and these trials did not include a structured lifting program. So the numbers above are what happens with drug plus usual lifestyle advice, not drug plus serious training. The tool we have the strongest evidence for protecting muscle is the one you control: resistance training. THE WORKOUT / TIPS The 2026 ACSM position stand on resistance training (an umbrella review of 137 reviews and 30,000+ participants) keeps it simple: train every major muscle group at least 2x per week, progress the load over time, and for muscle size aim for about 10 sets per muscle group per week. Training to failure, machines vs free weights and fancy periodization were optional, not required. Here is a 2-day full-body plan that hits those targets (do A and B each once a week; add a third day by repeating A when you're ready): DAY A 1. Goblet squat or leg press: 3 x 8-12 2. Dumbbell bench press or push-ups: 3 x 8-12

More than 25 people in at least four states got sick after compounded glutathione injections and IVs made from a supplement-grade ingredient, and the story is back in the news this weekend. (1)(2) WHAT IT IS Glutathione is a small peptide (three amino acids) that wellness clinics sell as IV drips and shots for "detox," immunity and energy. In July 2026, Texas health officials alerted the CDC to patients who got sick after IV glutathione at an outpatient wellness clinic. CDC and FDA have been investigating since. (1) WHAT THEY FOUND • CDC counts more than 25 cases in Texas, Washington, Florida and New York. At least 3 people were hospitalized, all after IV glutathione. One was critically ill, needed intensive care, and was treated for shock and abnormal blood clotting. No deaths are listed. (1) • FDA said it knew of at least 30 patients with adverse events after IV glutathione. The ingredient traced back to one supplier (Medisca, lot 229536) and was labeled "dietary supplement grade." (3) • Three Texas compounding pharmacies recalled products for elevated endotoxin: Victory Medical Center Pharmacy, Optimal Balance Pharmacy and Centric Compounding. (1)(4)(5) • Centric's recall also covered Myer's Cocktail and Tri-Immune Boost vials made with the same ingredient, shipped nationwide by home delivery. It received 9 reports of fever, chills, chest pain, nausea or vomiting, headache and malaise. (5) • Victory's reports included fever, chills, severe headache, vomiting, rapid heart rate, blood pressure changes and injection-site reactions. (4) HOW IT WORKS Endotoxin is a bacterial contaminant. Once injected, it can set off a strong inflammatory reaction: fever, chills, body aches, low blood pressure and, at worst, shock. (1)(5) The core problem was the raw material. FDA's position is that every ingredient in an injectable has to be made to standards that fit that route, and that testing the finished vial is not a substitute for building quality in from the start. (3)(6)

Retatrutide, Lilly's once-weekly "triple agonist," has now hit its main weight-loss goal in multiple Phase 3 trials. Here's where the evidence stands. WHAT IT IS Retatrutide activates three hormone receptors at once: GLP-1 and GIP (like tirzepatide) plus glucagon. The glucagon arm is thought to raise energy expenditure and help clear liver fat, on top of the appetite reduction from GLP-1/GIP. WHAT THE TRIALS FOUND (80 weeks, weekly injections, randomized vs. placebo) TRIUMPH-1: 2,339 adults with obesity/overweight, no diabetes • Average weight loss: 19.0% (4 mg), 25.9% (9 mg), 28.3% (12 mg) • At 12 mg, 45% of people lost 30% or more of their body weight • In a 104-week extension (BMI 35+), the 12 mg group averaged 30.3% loss TRIUMPH-2: 1,152 adults with type 2 diabetes and obesity/overweight • Weight loss: 12.7% / 19.1% / 20.8% vs. 4.0% placebo • A1C dropped about 1.4–1.6 points vs. 0.2 on placebo TRIUMPH-3: 1,949 adults with severe obesity and established heart disease • Weight loss: 21.6% (9 mg) and 22.6% (12 mg) vs. 3.2% placebo • Triglycerides fell 37%, systolic blood pressure about 9 mmHg, hsCRP (inflammation marker) about 51% at 12 mg • Heart-event results were inconclusive: too few events to show benefit or harm THE TRADE-OFFS • GI side effects are common and dose-related: nausea hit up to 42% at the top dose in TRIUMPH-1 (vs. 15% placebo), plus diarrhea, constipation and vomiting • Dysesthesia (abnormal skin sensations like tingling) showed up more than with placebo, mostly mild to moderate • Stopping due to side effects: roughly 4–13% depending on dose and trial, vs. about 5% on placebo HOW STRONG IS THIS? Strong: large, randomized, double-blind human trials. One caveat: TRIUMPH-2 and -3 are company-announced topline results; full peer-reviewed data is still to come. REGULATORY STATUS Investigational. Not FDA-approved for any use. Lilly says it plans to submit for U.S. approval in Q1 2027. Anything sold as "retatrutide" today is not an approved product.

Hey everyone! First off, I just want to say a massive THANK YOU for all the incredible support you've shown. Building this community has been amazing, and I appreciate every single one of you. To show my gratitude and make sure you get the absolute most out of the material, I'm dropping a huge bonus: Any purchase of the Peptide EDU Ebook now comes with FREE coaching for an entire year! Whether you are trying to dial in your protocols, need help understanding the science, or just want ongoing guidance and accountability from the Eternity Peptides team, we will be in your corner for the next 12 months. How to claim your year of free coaching: 1. Click on the Classroom tab at the top of the page. 2. Go to the Peptide EDU Ebook and complete your purchase. 3. Shoot me a direct message right here on Skool immediately after! 4. We will get your coaching access set up so we can get to work! Let's crush those optimization goals together. Thank you again for all the support! 🚀