You got an MTHFR result. Then what? For most people, that moment goes one of two ways. Your doctor glanced at it and said, "It's not clinically significant." Or you fell down a rabbit hole of contradictory websites, Facebook groups, and supplement protocols that left you more confused than when you started. Neither of those should happen. That's exactly why this community exists. I'm Jean-Marc — integrative physician, 25 years in clinical practice, and probably the only doctor you'll meet who gets genuinely excited about methylation genetics. I created The Methylation Hub because the gap between what the science tells us and what patients actually receive is one of the most unnecessary failures in modern medicine. You deserve better than a shrug or a supplement shopping list. This is what you'll find here Clinical depth without the jargon. Evidence-based answers to the questions your GP didn't have time for. A community of people who understand what it means to feel like your biology has been working against you — and are figuring it out together. Every Thursday at 8 pm UK time, I host a live Q&A. Bring your labs, your questions, your confusion. Nothing is too basic, and nothing is too complex. Sessions are recorded if you can't attend live. The Classroom will have structured modules on methylation fundamentals, supplement protocols, and fertility, with more added regularly. One thing before you do anything else Go to the Introductions category and answer this single question: What is your MTHFR variant, and what is the one question you most want answered? That's it. One question. I read every introduction personally and respond to each one. You're not joining a database. You're joining a conversation that could genuinely change how you understand your own health. Welcome. Jean-Marc Sobczyk, MD - The Methylation Doctor

I have been explaining the same things to patients for 25 years and posting about them for 3. It was scattered across hundreds of posts, and nobody could find anything, including me. So I rebuilt it. **The Archive** is 135 clinical explainers on methylation and MTHFR, organised by the question you are asking. Eleven modules, going up in the classroom one at a time, free: MTHFR Foundations · Reading Your Labs · COMT and Your Brain Chemistry · Homocysteine · B12 · Gut and Absorption · Why Supplements Backfire · Ageing and Biological Age · Environmental Drivers · Fertility and Pregnancy · Methylation and Neurodevelopment Every entry answers one question: the mechanism, what I see in clinic, and what it does not mean. Every claim is sourced and graded A to D, so you can tell a trial result from a good theory. Modules 1 and 2 are live. Search the index and start wherever your question is.

Here is a preview of the Handbook ⬇️ What's in this course The TRACE Method: Practical Methylation for MTHFR Seven modules, built around the same five-stage sequence I use with patients at Hooke London. Nothing here is theory; you have to translate it into action yourself. Each module ends where the next one starts. Module 0: Welcome & Foundations What MTHFR actually is, and why a variant is a ceiling, not a diagnosis. Start here even if you've read about MTHFR before; this reframes most of what's online. Module 1: Test Which markers matter, which ones don't, and why a genotype alone tells you almost nothing without the biochemistry around it. Module 2: Restore The foundational cofactors and pathway support most protocols skip. Why starting here, ahead of high-dose methylfolate, is what separates a result from a reaction. Module 3: Address The downstream systems methylation touches that most guides never mention. Detoxification. Neurotransmitter synthesis. Hormone clearance. Module 4: Correct How to titrate and adjust once you know your starting point, including why "more" is usually the wrong instinct with methyl donors. Module 5: Enable What keeps the gains, and how to tell whether you've moved the needle or you're just guessing. Bonus Module: Synthesis & Clinical Judgement Unlocks once Modules 1 through 5 are complete. Putting the five stages together into one working picture, the same judgement call I make in clinic. The modules are sequenced on purpose. Module 4 won't unlock until Modules 2 and 3 are done, the same way I wouldn't move a patient to Correct before Restore and Address have done their work. Also included: - The TRACE Roadmap, a printable one-page reference for all five stages - A glossary covering every term used in the course, in plain language - A Resources & References pack, the blood panel to request and the evidence behind each stage Who wrote this Dr Jean-Marc Sobczyk is a GMC-registered integrative and longevity medicine physician with 25 years of clinical experience across France, Switzerland, Beverly Hills and the UK. He practises at Hooke London, where methylation genetics sits at the centre of his clinical work.