Restraint and seclusion may only be used for safety purposes — seclusion specifically means involuntary confinement to manage violent or self-destructive behavior — and either may only be used when less restrictive interventions have been determined ineffective at protecting the patient, staff, or others. Why this is your go-to “patient rights in disputes” citation: it’s the single federal regulation that covers grievances, informed consent/refusal, restraint/seclusion justification, privacy, and abuse-free care all in one place — which is exactly why it gets invoked so often when a nurse is defending a decision about a refused treatment, a restraint application, or a patient/family complaint.